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Biotin is believed to help support our hair, skin and nails, as well as deliver several other health benefits. However, biotin’s ability to help in these three areas, particularly hair, is yet to be widely proven. Choosing a biotin supplement or a multivitamin for hair, skin and nails is often the best bet if you want to make sure you’re getting enough. How much biotin should I take? A lot of people who are looking for biotin supplements to help support their hair health – is that you?
Although rare, biotin deficiency can cause skin rashes, brittle nails, as well as hair thinning and loss. This owes to the vitamin’s role in keratin production ( 2, 3). Eggs are a good source of biotin, a complex B vitamin that helps your body turn nutrients into energy and provides a variety of health benefits. (Photo Credit: Moment / Getty Images) Langova L, Novotna I, Nemcova P, Machacek M, Havlicek Z, Zemanova M, Chrast V (October 2020). "Impact of Nutrients on the Hoof Health in Cattle". Animals. 10 (10): 1824. doi: 10.3390/ani10101824. PMC 7600182. PMID 33036413.Chemically modified versions of biotin are widely used throughout the biotechnology industry to isolate proteins and non-protein compounds for biochemical assays. [34] Because egg-derived avidin binds strongly to biotin with a dissociation constant K d ≈ 10 −15M, [35] biotinylated compounds of interest can be isolated from a sample by exploiting this highly stable interaction. First, the chemically modified biotin reagents are bound to the targeted compounds in a solution via a process called biotinylation. The choice of which chemical modification to use is responsible for the biotin reagent binding to a specific protein. [34] Second, the sample is incubated with avidin bound to beads, then rinsed, removing all unbound proteins, while leaving only the biotinylated protein bound to avidin. Last, the biotinylated protein can be eluted from the beads with excess free biotin. [36] The process can also utilize bacteria-derived streptavidin bound to beads, but because it has a higher dissociation constant than avidin, very harsh conditions are needed to elute the biotinylated protein from the beads, which often will denature the protein of interest. [35] Interference with medical laboratory results [ edit ] The European Food Safety Authority (EFSA) also identifies AIs, setting values at 40μg/day for adults, pregnancy at 40μg/day, and breastfeeding at 45μg/day. For children ages 1–17 years, the AIs increase with age from 20 to 35μg/day. [10] Safety [ edit ] In the United States, biotin is promoted as a dietary supplement for strengthening hair and fingernails, though scientific data supporting these outcomes in humans are very weak. [3] [55] [56] A review of the fingernails literature reported brittle nail improvement as evidence from two pre-1990 clinical trials that had administered an oral dietary supplement of 2.5mg/day for several months, without a placebo control comparison group. There is no more recent clinical trial literature. [55] A review of biotin as treatment for hair loss identified case studies of infants and young children with genetic defect biotin deficiency having improved hair growth after supplementation, but went on to report that "there have been no randomized, controlled trials to prove efficacy of supplementation with biotin in normal, healthy individuals." [56] Biotin is also incorporated into topical hair and skin products with similar claims. [57]
It’s also worth noting that if you have ‘extra’ biotin in your body, it will naturally be flushed out of your system when you urinate.
What Does a Biotin Supplement Contain?
It’s a very busy and often underlooked vitamin! Biotin has multiple important functions in the body, including: 3 Biotin is a type of B vitamin, also known as vitamin H. It is essential for allowing a group of enzymes to break down some substances and activate certain other enzymes responsible for helping the body produce myelin — an insulating layer that wraps around nerves, allowing transmission of electrical impulses. The enzyme holocarboxylase synthetase covalently attaches biotin to five human carboxylase enzymes: [4]
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